Respiratory failure occurs when the balance between the load on the respiratory system and its capacity to manage that load is disrupted. This talk, presented by Professor Mike Polkey, explores the mechanisms behind respiratory failure, focusing on factors such as respiratory muscle weakness, increased load from conditions like obesity or scoliosis, and central control issues during sleep. It also examines how diseases like COPD and neuromuscular disorders affect respiratory mechanics, the role of pressure-volume relationships, and why interventions such as non-invasive ventilation (NIV) are critical. The session emphasises practical insights into physiology, clinical implications, and strategies for managing respiratory failure effectively.
